抄読会；保富ｄｒContributions of Pneumolysin, Pneumococcal Surface Protein A (PspA), and PspC to Pathogenicity of Streptococcus pneumoniae D39 in a Mouse Model

Contributions of Pneumolysin, Pneumococcal Surface Protein A (PspA), and PspC to Pathogenicity of Streptococcus pneumoniae D39 in a Mouse Model

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1865719/

nasal wash vs. nasal tissue(trypsine) -> 菌量比較　トリプシン処理後の方が菌量が増す

wild type D39株のpneumolysin(Ply)にmutationを起こさせ、付着、病原性の獲得、菌量増加を検討。

flu感染の前処置によって肺炎球菌菌量が増加する。しかし、PspAの経鼻免疫を行うと鼻咽腔保菌量の低下、肺障害性の低下が見られる。